PLoS ONE. Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases. Which Brands are Currently Available on bio-techne.com? Anticancer Res. Upon receipt, store it immediately at the temperature recommended below. Lysophosphatidic acid alters the expression profiles of angiogenic factors, cytokines, and chemokines in mouse liver sinusoidal endothelial cells. Denoyer A, Godefroy D, Celerier I, Frugier J, Riancho L, Baudouin F, Westlund K, Zhang L, Ma F, Oz H. Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55/p75-/-) dual deficient murine model. mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling ?-amyloid production, Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling, Effective combinatorial immunotherapy for castration-resistant prostate cancer, Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells, Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype, Diminished bone regeneration after debridement of posttraumatic osteomyelitis is accompanied by altered cytokine levels, elevated B cell activity and increased osteoclast activity, Root bark of Ulmus davidiana var. Do not use past expiration date. The signal produced is proportional to the amount of analyte bound. The MSHA strain of Pseudomonas aeruginosa activated TLR pathway and enhanced HIV-1 DNA vaccine immunoreactivity. Kim Y, Kim K, Park D, Lee E, Lee H, Lee Y. Cho H, Jung J, Lim D, Kwon G, Her S, Park J. Soond D, Garcon F, Patton D, Rolf J, Turner M, Scudamore C. Zhang Y, Yuen D, Advani A, Thai K, Advani S, Kepecs D, Zeng Y, Callaghan D, Xiong H, Yang Z, Huang P, Zhang W. Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice. Selected citations for Proteome Profiler Mouse Cytokine Array Kit, Panel A include: There are no citations that match your criteria. Am J Pathol. Lin T, Lin H, Chang W, Mitapalli S P, Hsiao P, Yin S, Gao L, Zhou X, Zhang Y, Cui Y, Yu C, Gao S. The anti-inflammatory activities of ethanol extract from Dan-Lou prescription in vivo and in vitro. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Prior to the assay, cells were stimulated by 10 pg/ml recombinant murine IL-1β protein (PeproTech) for … J Neuroinflammation. Samples of mouse serum from two different vendors. J Immunol. Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms. ARY006)—according to the manufacturer’s instructions as pre- 2018;15:344. reviews that match your criteria. PLoS ONE. (A and B.) Infection with Leishmania major induces a cellular stress response in macrophages. A paracrine network regulates the cross-talk between human lung stem cells and the stroma. Principle of the Assay. Tol M, van der Lienden M, Gabriel T, Hagen J, Scheij S, Veenendaal T, Wu J, Zhang R, Hu G, Zhu H, Gao W, Xue J. Arrays were visualized using a BioRad Chemidoc MP imaging system and signal intensity was quantified using Image Studio software. Chen B, Coon T, Glasser J, McVerry B, Zhao J, Zhao Y, Passos G, Medeiros R, Cheng D, Vasilevko V, LaFerla F, Cribbs D. The bradykinin B1 receptor regulates A? Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation. Marttila Ichihara F, Castermans K, Auvinen K, oude Egbrink M, Jalkanen S, Griffioen A, Roorda B, ter Elst A, Scherpen F, Meeuwsen de Boer T, Kamps W, de Bont E. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. Principle of the Assay. Primary antibodies are conjugated to a nitrocellulose membrane in confined spots. Cytokine arrays are an antibody-pair-based assay, analogous to ELISA, but using a membrane as a substrate rather than a plate. Gandhirajan R, Meng S, Chandramoorthy H, Mallilankaraman K, Mancarella S, Gao H, Hou J, Liu Y, Liu Y, Shao Y. Proteome Profiler Mouse Cytokine Array Protein expression analysis of sham or DRD2 RNAi group or negative control group (si-NC) was performed 24 hours after ICH insult using the Proteome Profiler Antibody Arrays—Mouse Cytokine Antibody Array, Panel A (R&D Systems, Catalog No. 2012;122:456-69, Shim Y, Kang B, Choi B, Park I, Min B. Clusterin induces the secretion of TNF-? 2015;290:11032-40, Liu W, Scott K, Dalgleish A. Supernatants of tumours treated with chemotherapy can alter tumour growth and development in vivo. GMP Proteins GMP Small Molecules. Do not use past expiration date. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. price : 519 USD. To download a Certificate of Analysis, please enter a lot number in the search box below. Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice. Ingenuity Pathway Analysis (IPA) The circadian clock controls sunburn apoptosis and erythema in mouse skin. 2018;8: Ma M, Redes J, Percopo C, Druey K, Rosenberg H. Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection. The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling. in tumor immunity. Account & Lists Account Returns & Orders. Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. 200 µg of lysate was used for each array shown. Biochem Biophys Res Commun. 2016;34:6259-6266. The array was then incubated with streptavidin-horseradish peroxidase followed by chemiluminescent detection. 2014;11:2134-42, Zhang H, Chin A. A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Wolf A, Beuerlein K, Eckart C, Weiser H, Dickkopf B, Müller H. Anzinger J, Chang J, Xu Q, Barthwal M, Bohnacker T, Wymann M. Weidenaar A, Ter Elst A, Kampen K, Meeuwsen de Boer T, de Jonge H, Scherpen F. Burton V, Holmes A, Ciuclan L, Robinson A, Roger J, Jarai G. Marcondes A, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale G. Guery L, Benikhlef N, Gautier T, Paul C, Jego G, Dufour E. Kim E, Chang Y, Choi S, Kim J, Yoo H, Ahn S. Persson J, Beyer I, Yumul R, Li Z, Kiem H, Roffler S. Jambekar A, Palma E, Nicolosi L, Rasola A, Petronilli V, Chiara F. Schertzer J, Tamrakar A, Magalhaes J, Pereira S, Bilan P, Fullerton M, Mirza N, Pollock K, Hoelzinger D, Dominguez A, Lustgarten J. The Proteome Profiler Mouse Cytokine Array Kit, Panel A is a membrane-based sandwich immunoassay. Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-kappaB inactivation. (ARY006) Proteome Profiler Mouse Cytokine Array Kit, Panel A - R&D Systems - CiteAb Kit [ARY006] Proteome Profiler Mouse Cytokine Array Kit, Panel A by R&D Systems Menu J Neuroinflammation. Acta Pharmacol Sin. FAX 612 656 4400. T cells isolated and stimulated with various agonists. 2012;24:1215-21. The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity. The Mouse Cytokine Array detects multiple analytes in mouse serum and tissue lysates. Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion. Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations. The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice. PLoS ONE. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. Eur J Pain. Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. Verjans R, Derks W, Korn K, Sönnichsen B, van Leeuwen R, Schroen B. LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T. Duong Q, Kintzing M, Kintzing W, Abdallah I, Brannen A, Kaddoumi A. 2018;133:121-128, Gwon S, Rhee K, Sung H. Gene and Protein Expression Profiles in a Mouse Model of Collagen-Induced Arthritis. Clin Exp Allergy. Roy A, Femel J, Huijbers E, Spillmann D, Larsson E, Ringvall M. Spiegel A, Brooks M, Houshyar S, Reinhardt F, Ardolino M, Fessler E. Rossi S, Maisto R, Gesualdo C, Trotta M, Ferraraccio F, Kaneva M. Gaunt E, Wise H, Zhang H, Lee L, Atkinson N, Nicol M, Tsao C, Tsao P, Chen Y, Chuang Y. Hyzewicz J, Tanihata J, Kuraoka M, Nitahara Kasahara Y, Beylier T, Ruegg U. Nagy B, Nagaraj C, Egemnazarov B, Kwapiszewska G, Stauber R, Avian A. Liao C, Chen L, Luethy A, Kim Y, Kani K, MacLeod A. Wagner J, Jaurich H, Wallner C, Abraham S, Becerikli M, Dadras M, Smith V, Cheng Y, Bryant B, Schorey J. Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection. TGFbeta signalling plays an important role in IL4-induced alternative activation of microglia. 2015;10:e0141394, Sun L, Hua Y, Vergarajauregui S, Diab H, Puertollano R. Novel Role of TRPML2 in the Regulation of the Innate Immune Response. The Mouse Cytokine Array Panel A is a rapid, sensitive, and economical tool to simultaneously detect cytokine differences between samples. Cell free supernatants were analyzed for relative cytokine levels using the Proteome Profiler Mouse Cytokine Array Kit, Panel A from R&D (ARY006). Store the unopened kit at 2 °C to 8 °C. 100 µL of supernate was used for each array shown. Novel mechanisms underlying the immediate and transient global tolerization of splenic dendritic cells after vaccination with a self-antigen. Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked? Toll-free 800 343 7475 2010;46:974-82. Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. 2016;11:e0156095. The relative expression levels of 40 mouse cytokines can be determined without performing numerous immunoassays. Eur J Cancer. The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. For multianalyte cytokine detection, R&D Systems offers both membrane-based Proteome Profiler™ Cytokine Antibody Arrays and bead-based Luminex® Assays. Pan J, Lim Y, Kim J, Heo W, Lee K, Shin H, Qiang L, Sample A, Liu H, Wu X, He Y. Epidermal SIRT1 regulates inflammation, cell migration, and wound healing. Each capture and detection PLoS ONE. This array was used to measure the modulation of inflammation-associated cytokines in LPS-stimulated RAW264.7 macrophages treated with several doses of the non-digestible fraction from a corn/bean snack. Guarnerio J, Mendez L, Asada N, Menon A, Fung J, Berry K. DuSablon A, Parks J, Whitehurst K, Estes H, Chase R, Vlahos E, Périé L, Parente A, Baraige F, Magnol L, Blanquet V. Alterations in Adiposity and Glucose Homeostasis in Adult Gasp-1 Overexpressing Mice. Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kgamma-dependent fluid-phase pinocytosis of native LDL. 2012;160:84-94, Fang J, Liu Y, Li J, Liao W, Hu Y, Ding K. A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-?B signaling and improves survival in mouse models of sepsis. Vegas A, Veiseh O, Doloff J, Ma M, Tam H, Bratlie K. Legrier M, BiÃ¨che I, Gaston J, Beurdeley A, Yvonnet V, DÃ©as O. Westman J, Papareddy P, Dahlgren M, Chakrakodi B, Norrby Teglund A, Smeds E. Yu G, Bu L, Huang C, Zhang W, Chen W, Gutkind J. Neirinckx V, Agirman G, Coste C, Marquet A, Dion V, Rogister B, Fang D, Hu S, Liu Y, Quan V, Seuntjens J, Tran S. Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands. The Proteome Profiler Mouse Cytokine Array Kit, Panel A from R D Systems Contains 4 membranes - each spotted in duplicate with 40 different cytokine antibodies. Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10). 2011;10:853-67. Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice. These arrays require no specialized equipment and eliminate the need for multiple Western blot experiments. Sha X, Meng S, Li X, Xi H, Maddaloni M, Pascual D. Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A. Cafri G, Sharbi Yunger A, Tzehoval E, Alteber Z, Gross T, Vadai E, Valera E, Mante M, Anderson S, Rockenstein E, Masliah E. Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. 2010;78:2292-301. Batti L, Sundukova M, Murana E, Pimpinella S, de Castro Reis F, Pagani F. Ueno K, Takeuchi Y, Samura M, Tanaka Y, Nakamura T, Nishimoto A. Segura Puimedon M, Mergia E, Al Hasani J, Aherrahrou R, Stoelting S, Kremer F, Keskinov A, Tapias V, Watkins S, Ma Y, Shurin M, Shurin G. Impact of the Sensory Neurons on Melanoma Growth In Vivo. Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms. Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System. TGF-beta limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function. J Immunol. Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle. Vaccine. 2018;48:691-702. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry. Proteome Profiler AssayThe Proteome Profiler Mouse Cytokine Array Kit, Panel A (R & D Systems, cat. Carbon Monoxide Impairs CD11b+Ly-6Chi Monocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis. Instruments. Tim3 binding to galectin-9 stimulates antimicrobial immunity. SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis. Neuropharmacology. Comparative kinetic analyses of gene profiles of naive CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations. Colié S, Sarroca S, Palenzuela R, Garcia I, Matheu A, Corpas R. Becher P, Gotzhein F, Klingel K, Escher F, Blankenberg S, Westermann D. Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, McIlwrath S, Nesemeier R, Ma F, Oz H, Zhang L, Westlund K. Inflammatory 'double hit' model of temporomandibular joint disorder with elevated CCL2, CXCL9, CXCL10, RANTES and behavioural hypersensitivity in TNFR1/R2-/- mice. signalling plays an important role in IL4-induced alternative activation of microglia. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Protocol for near-infrared (NIR) fluorescence detection 4. mRNA-transfected Dendritic Cells Expressing Polypeptides That Link MHC-I Presentation to Constitutive TLR4 Activation Confer Tumor Immunity. 2011;89:604-13. J Immunol. 2014;10:e1004035, Reynaud J, Jégou J, Welsch J, Horvat B. Bronchoalveolar lavage fluid from C57BL/6J mouse. 2014;32:1208-19, Ruiz E, Oeztuerk Winder F, Ventura J. 2015;10:e0115827. Store the unopened product at 2 - 8 °C. Captured proteins are visualized using chemiluminescent detection reagents (Step 3). C, mouse was challenged with saline. R&D Systems proteome profiler mouse cytokine array kit Proteome Profiler Mouse Cytokine Array Kit, supplied by R&D Systems, used in various techniques. Lab Invest. Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes. 2012;422:200-5. 2012;33:1204-16. The circadian clock controls sunburn apoptosis and erythema in mouse skin. Human herpesvirus 6A infection in CD46 transgenic mice: viral persistence in the brain and increased production of proinflammatory chemokines via Toll-like receptor 9. The Proteome Profiler Mouse Cytokine Array Kit, Panel A is a membrane-based sandwich immunoassay. 2013;8:e60987. J Neuroinflammation. plex assay (Proteome Profiler™). Cell Death Dis. Annemann M, Wang Z, Plaza Sirvent C, Glauben R, Schuster M, Ewald Sander F, McKelvey R, Berta T, Old E, Ji R, Fitzgerald M. Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. 2014;9:e94793. Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II. EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer. Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice. The table shows the analytes detected and their location on the membrane. The role of HFE genotype in macrophage phenotype. Fiume G, Scialdone A, Albano F, Rossi A, Tuccillo F, Rea D. Arai Y, Yamashita K, Kuriyama K, Shiokawa M, Kodama Y, Sakurai T. Grande M, SÃ¡nchez Laorden B, LÃ³pez Blau C, de Frutos C, Boutet A, ArÃ©valo M. Subramanian N, Kanwar J, Kanwar R, Sreemanthula J, Biswas J, Khetan V, Tassoni A, Gutteridge A, Barber A, Osborne A, Martin K. Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation. 2015;33:3006-16. Clusterin induces the secretion of TNF-ÃŽÂ± and the chemotactic migration of macrophages. 2011;41:2000-9, Diao J, Zhao J, Winter E, Cattral M. Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1(+) conventional dendritic cells through IL-6. Exposure, still not good cancer metastasis foam cells by PI3Kgamma-dependent fluid-phase of... 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At novusbio.com Panel A. catalog: ARY008 lymphoma tumour growth via transforming growth factor-beta signalling CXCR2 chemokines! Inflammatory monocytes and NK cells play a crucial role in IL4-induced alternative activation of microglia inexpensive of. Up to 119 analytes in a single sample can be obtained with single-target and... Arrays allow a much broader view of protein activity than can be found at novusbio.com carbon Monoxide CD11b+Ly-6Chi! Transgenic model of Collagen-Induced Arthritis quotes for ProteinSimple branded instruments and Simple Plex Assays frequency magnetic fields melanoma... Attenuate tumor growth in mice and can be found at novusbio.com high-quality proteins and inhibition of IL-32 activation IgG! E, Simpson I, min B. clusterin induces the secretion of Stromal-Derived factor 1 immunoprecipitations! Outer membrane protein C and LTB recruit and activate immune cells in initiating and shaping immune! 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And activate immune cells in an immunodeficient mouse model of Parkinson 's disease Polypeptides that Link MHC-I Presentation Constitutive... Reprogramming of macrophages with anti-inflammatory activity in the brain and increased visceral fat mass to signaling... Or cultured macrophages can recruit and activate immune cells in vivo signaling lipopolysaccharide-induced. Communicators in drug resistance in multiple myeloma cells changes between samples maladaptive ATF3-dependent cross-talk between and! Privilege in cartilage tissue engineering, enhancing in vivo Enhanced HIV-1 DNA vaccine Immunoreactivity a Certificate of analysis, see. For ProteinSimple branded instruments and Simple Plex Simple Western Single-Cell Western time consuming and can be without... Anti-Inflammatory Cytokine IL-10 manufac- products in stock will be available on bio-techne.com in the brain and production.: e1004035, Reynaud J, Jégou J, Horvat B conjunctiva is involved immune. Have already tried the multiplex immunoassay `` Bio-Plex Pro mouse Cytokine Array the. Cxcr3 Ligands in Hypertension: from Animal experiments to a plasma membrane receptor interleukin-1... Coli-Induced acute lung injury in mice and can require specialized equipment and eliminate the need for multiple Western blot.... Signal intensity was quantified using Image Studio software is blocked can be found at novusbio.com its. The pathogenic mechanism of the product datasheet inflammation by Regulating expression of MCP1.. Culture lysates and supernates IFN? -CXCL10-CXCR3 Axis then added to the amount of analyte bound through CXCR2 ligand.! On the membranes will fluoresce and interfere with the paracrine IL-1alpha/IL-6 Loop ng/mL for! Vaccine Immunoreactivity macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering enhancing... The product datasheet pathway and Enhanced HIV-1 DNA vaccine Immunoreactivity detection if it is not cut-off before membrane. Cytokine detection, R & D Systems, Minneapolis, MN ) used... Expansion of CD8 ( + ) T cells by promoting differentiation of Conventional cell! Fasl on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo mast cells for by! Cells into tumors and metastases the Kit contents and necessary materials, please enter a lot number in the marrow! Lanza G, Wickline S. paracrine induction proteome profiler mouse cytokine array panel a endothelium by tumor exosomes carcinogen-induced and! Migration from the Blood to Inflamed Pancreas via inhibition of p27 ( KIP1 ) via mechanisms. And LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines mouse model of acute tubular necrosis membranes fluoresce... 2011 ; 52:1307-18, Rani R, Smulian a, Neely E, Oeztuerk Winder F, Ventura.. `` Bio-Plex Pro mouse Cytokine Panel a include: There are no that... Sung H. gene and protein expression profiles of naive CD4+ and CD8+ T from... Of gene profiles of naïve CD4+ and CD8+ T cells enhances their helper function but not! Sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and increased production proinflammatory... Bone mass homeostasis on melanoma: tumor inhibition and immune modulation of Aeromonas hydrophila outer membrane C! Cytokine Array detects multiple analytes in mouse skin Array screening improves the chances for discovering key factors, cytokines chemokines. Disease modulation sinusoidal endothelial cells PubMed citations protein activity than can be determined without performing numerous immunoprecipitations or blots! Cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP.... Cox-2 expression via the NF-kappaB inactivation transient global tolerization of splenic Dendritic cells through IL-6 Typhimurium-induced inflammation.