American Cancer Society medical information is copyrighted material. Connect with thousands of members with your diagnosis and learn from their experiences. National Cancer Institute. Recurrence of cervical cancer outside of the pelvis is more challenging to treat, but include many of the same treatment methods for more advanced stages of cervical cancer [49]. As the cancer spreads, the chances of successful treatment This means that 5 This is a major operation that takes around 6 to 12 weeks to recover from. With this treatment, you have chemotherapy during your course of radiotherapy.You have daily external radiotherapy for 5 days every week, for around 5 weeks. It is usually done under a local anaesthetic. Surgery to remove pelvic lymph nodes followed by radiation therapy with or without chemotherapy. We value your privacy. Cervical cancer is the fourth most common cancer in the world for women, affecting over half a million people every year. 11th ed. The targeted drug bevacizumab (Avastin) may be added to chemo or immunotherapy alone with pembrolizumab (Keytruda) Abeloff’s Clinical Oncology. A simple hysterectomy may be an option if the cancer shows no lymphovascular invasion and the edges of the biopsy have no cancer cells. may also be an option. Until we do, we’ll be funding and conducting research, sharing expert information, supporting patients, and spreading the word about prevention. The treatment of cervical cancer varies with the stage of the disease (see Cervical Cancer Staging). It does, however, represent a progression of the cancer and a worsening prognosis for the patient. Surgery combined with radiotherapy and chemotherapy can be applied for Stage 1B treatment. Most cervical cancers are diagnosed at an early stage. Chemoradiation: The chemo may be cisplatin, carboplatin, or cisplatin plus fluorouracil. 2019. https://www.cancer.gov/types/cervical/hp/cervical-treatment-pdq. Clinical trials of new anticancer drugs or drug Stage 1B cervical cancer treatment is determined by your doctor according to factors such as the type of cell, its location, and the person’s health. Imaging tests or evaluation of tissue samples can also be used to determine tumor size. Chapter 74: Cancer of the Cervix, Vagina, and Vulva. New treatments that may benefit patients who have distant recurrence of cervical cancer are being evaluated in clinical trials. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. It’s also important to follow recommended screening guidelines, which can help detect certain cancers early. (800) 925-4456 | You can help reduce your risk of cancer by making healthy choices like eating right, staying active and not smoking. for early cervical cancer – surgery to remove the cervix and some or all of the womb, or radiotherapy, or a combination of both for advanced cervical cancer – radiotherapy with or without chemotherapy, and surgery is also sometimes used Cervical cancer is often curable if it's diagnosed at an early stage. surgery. Patient Engagement Portal v.6.0 | All so you can live longer — and better. The survival rates for women with early-stage cervical cancer who have standard treatment are excellent. women who cannot or no longer want to have children. Factors that may influence cervical cancer treatment include: the stage of the cancer, the size of the tumor, the patient's desire to have children, and the patient's age. Treatment options include radiation therapy with or without chemo to try to slow … If the cancer has recurred in the center of the pelvis only, extensive surgery (such as pelvic exenteration) may be an option for some patients, and offers the best chance for possibly curing the cancer (although it can have major side effects). Another option is a radical trachelectomy along with removal of the pelvic lymph nodes. Together, we’re making a difference – and you can, too. The chemo may be cisplatin, carboplatin, or cisplatin plus fluorouracil. We’ve invested more than $4.9 billion in cancer research since 1946, all to find more – and better – treatments, uncover factors that may cause cancer, and improve cancer patients’ quality of life. feature in order to take full advantage of this site. Chemotherapy as palliative therapy to relieve symptoms caused by the cancer and improve quality of life. For early invasive cancer, surgery is the treatment of choice. with chemotherapy given at the same time. Radiation therapy The surgeon removes the cervix, part of the vagina, and the pelvic lymph nodes while leaving the uterus in place. The impact of cervical cancer on your daily life will depend on the stage of cancer and the treatment you're having. This is done only if the tumor cannot be completely removed by conization. If not, treatment would be radical hysterectomy and/or radiation. 1 Early-stage cervical cancer rate increased because of the development of diagnosis technique and screening test. The American Cancer Society medical and editorial content team. Surgery is the main cervical cancer treatment. LLETZ is the most common method to remove cervical tissue for examination and treating precancerous changes of the cervix. For example, sometimes chemo can improve your quality of life, and other times it might diminish it. therapy for women who cannot have surgery. If the edges of the cone don’t contain cancer cells (called negative margins), the woman can be watched closely without further treatment as long as the cancer doesn’t come back. But other factors can also affect your treatment options, including the exact location of the cancer within the cervix, the type of cancer (squamous cell or adenocarcinoma), your age and overall health, and whether you want to have children. Cancer.org is provided courtesy of the Leo and Gloria Rosen family. The treatment plan during pregnancy is determined by: If the cancer is at a very early stage, such as stage IA, most doctors believe it is safe to continue the pregnancy to term and have treatment several weeks after birth. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. Stage IA: The cancer is diagnosed only by viewing cervical tissue or cells under a microscope. If you decide to continue the pregnancy, the baby should be delivered by cesarean section (C-section) as soon as it is able to survive outside the womb. Generally, the earlier cervical cancer is diagnosed and treated, the better the outcome. A higher number, such as stage IV, means a more advanced cancer. For information about side effects caused by treatment for cancer, see our Side Effects page. lymph nodes. Privacy Policy | Cervical cancer stage ranges from stages I (1) through IV (4). Skrzypczyk-Ostaszewicz A, Rubach, M. Gynaecological cancers coexisting with pregnancy – a literature review. Cervical cancer – post treatment Stage 3b treatment without chemo Log in to add post Username * Password * feed me To prevent automated spam submissions leave this field empty. Help make it a reality. What patients and caregivers need to know about cancer, coronavirus, and COVID-19. Jhungran A, Russell AH, Seiden MV, Duska LR, Goodman A, Lee S, et al. We couldn’t do what we do without our volunteers and donors. Chemoradiation followed by a hysterectomy. If none of the lymph nodes have cancer cells, radiation may still be an option if the tumor is large, if the tumor has grown into blood or lymph vessels, or if the tumor is invading the surrounding connective tissue that supports organs such as the uterus, bladder, vagina (the stroma). The American Cancer Society couldn’t do what we do without the support of our partners. Cancer that comes back after treatment is called recurrent cancer. Cervical cancer treatment modalities include surgery, radiation therapy, chemotherapy and targeted therapy. The earliest stage of disease can be treated with surgery alone. At this stage, the cancer has spread out of the pelvis to other areas of the body. Treatment for cervical cancer may cause side effects. This depends on the chemotherapy drugs you have. You usually have surgery or a combination of chemotherapy and radiotherapy (chemoradiotherapy). Chemotherapy with radiation is generally used to treat stage II, stage III, and stage IV cervical cancer. cancer may include the following: Learn about treatment If the cancer has grown into blood or lymph vessels, you might need a radical hysterectomy along with removal of the pelvic lymph nodes. Introduction Cervical cancer is the fourth most frequent cancer in women, and about 570,000 new cases were diagnosed in 2018, representing 6.6% of all female cancers. Treatment may be delayed until the baby is born if you are in your third trimester of pregnancy or if the No matter which type of treatment your doctor recommends, it's important that you understand the goal of treatment (to try to cure the cancer, control its growth, or relieve symptoms), as well as its possible side effects and limitations. Radical hysterectomy with pelvic lymph node dissection and para-aortic lymph node sampling: If cancer cells are found in the removed lymph nodes, or in the edges of the tissue removed (positive margins), surgery may be followed by radiation therapy, which is often given with chemo (concurrent chemoradiation). therapy to relieve symptoms caused by the cancer and improve Updated February 6, 2019. Most standard chemo regimens include a platinum drug (cisplatin or carboplatin) along with another drug such as paclitaxel (Taxol), gemcitabine (Gemzar), or topotecan. Stage IVB cervical cancer is not usually considered curable. Whether you want to learn about treatment options, get advice on coping with side effects, or have questions about health insurance, we’re here to help. Hysterectomy for January 1, 2021. Stage IVB cervical cancer is not usually considered curable. Surgery options after birth for early-stage cancers include a hysterectomy, radical trachelectomy, or a cone biopsy. Deciding on the kind of treatment depends … This information updated … They may be used alone or in combination depending on tumor volume, spread pattern, and FIGO staging. If the edges of the biopsy have cancer cells present, a repeat cone biopsy or a radical hysterectomy with removal of the pelvic lymph nodes might be an option. Total hysterectomy (surgical removal of the uterus) is the standard treatment for women with cervical adenocarcinoma in situ and post-reproductive. Click here to refresh now Examples of early stage cervical cancer surgeries include: cone biopsy, trachelectomy (a fertility-sparing surgery) … on a form, click on the submit button to save your work. Radiation with or without chemotherapy: The radiation therapy includes both external beam radiation and brachytherapy. Stage IVB. Your doctor may have reasons for suggesting a treatment plan different from these general treatment options. The radiation therapy includes both external beam radiation and brachytherapy. An Introduction to Cervical Cancer Treatment by Stage Making Strides Against Breast Cancer Walks, Common Questions About the COVID-19 Outbreak, Treatment Options for Cervical Cancer, by Stage. Cone biopsy with removal of pelvic lymph nodes (pelvic lymph node dissection), Radical trachelectomy with pelvic lymph node dissection, Radical hysterectomy with removal of pelvic lymph nodes, Radical trachelectomy with pelvic lymph node dissection and sometimes removal of the para-aortic lymph nodes. Treatment of carcinoma in situ may include the following: Stage IA cervical cancer is separated into stage IA1 and IA2. After chemotherapy and radiation are complete, your healthcare provider may also suggest a hysterectomy. This can be treated with a repeat cone biopsy or a. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf on December 12, 2019. We can even find you a free ride to treatment or a free place to stay when treatment is far from home. 6th ed. At this stage, the cancer has spread out of the pelvis to other areas of the body. the National Cancer Institute and other experts. The NCCN guideline suggested that Tax ID Number: 13-1788491. Treatment for this stage depends on whether or not you want to be able to have children (maintain fertility) and whether or not the cancer has grown into blood or lymph vessels (called lymphovascular invasion). Internal radiation Start now! If the cancer has grown into blood or lymph vessels, one treatment option is a cone biopsy (with negative margins) with removal of pelvic lymph nodes. The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. Treatment for cervical cancer Your treatment depends on where in the cervix your cancer is, how big it is, whether it has spread anywhere else in your body and your general health. Imaging tests or evaluation of tissue samples can also be used to determine tumor size. Physician Data Query (PDQ). quality of life. You need to discuss this with your doctor. Certification General information about clinical trials is also available. As a rule, the lower the number, the less the cancer has spread. Treatment of stage IB and stage IIA cervical cancer may include the following: Radiation therapy with chemotherapy given at the same time. The following is an overview of the treatment of stage III cervical cancer. This site does not provide medical advice, diagnosis, or treatment. Patients with stage III cervical cancer are generally treated with radiation therapy and chemotherapy. Imagine a world free from cancer. Whether you or someone you love has cancer, knowing what to expect can help you cope. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. JavaScript is disabled in your web browser! At the American Cancer Society, we’re on a mission to free the world from cancer. Start now! Clinical trials are testing other combinations of chemo drugs, as well as some other experimental treatments. No one treatment is considered better than the other when it comes to cervical cancer or any cancer for that matter. More advanced cancers typically need be treated immediately. Sometimes chemotherapy can be given during the pregnancy (in the second or third trimester) to shrink the tumor. Chapter 84: Cancers of the Cervix, Vulva, and Vagina. Physician Data Query (PDQ®) Cancer Information Summaries on. Cancer can come back locally (in or near where it first started, such as the cervix, uterus or nearby the pelvic organs), or it can come back in distant areas (such as the lungs or bone). But other factors can also affect your treatment options, including the exact location of the cancer within the cervix, the type of cancer (squamous cell or adenocarcinoma), your age and overall health, and whether you want to have children. Treatment of stage IIB, stage III, and stage IVA cervical cancer may include the following: Radiation therapy with chemotherapy given at the same time. If none of the lymph nodes are found to have cancer, radiation may still be discussed as an option if the tumor is large, if the tumor has grown into blood or lymph vessels, or if the tumor is invading the surrounding connective tissue that supports organs such as the uterus, bladder, vagina (the stroma). Don't hesitate to ask him or her questions about your treatment options. The information is intended to help educate you about treatment options and to facilitate a shared decision-making process with your treating physician. Please enable this If the cancer is stage IB or higher, then you and your doctor must decide whether to continue the pregnancy. Treatment options include radiation therapy with or without chemo to try to slow the growth of the cancer or help relieve symptoms . Radical hysterectomy and pelvic lymphadenectomy are also recommended. Your treatment plan is based on the clinical stage. Total hysterectomy with or without bilateral salpingo-oophorectomy. In the earliest stages (stage IA) at five years after diagnosis, approximately 95 percent of women are alive. Impact of Histological Subtype on Cervical Cancer Survival 341 2020). Research. radiation therapy to the pelvis, plus chemotherapy. Conization, such as cold-knife conization, loop electrosurgical excision procedure (LEEP), or laser Radiotherapy or chemoradiation (radiotherapy given with chemotherapy) is sometimes used: instead of surgery, if you Surgery, radiation, chemotherapy or a combination of the three may be used. A cone biopsy is used where there are abnormal glandular cells in the cervix or if early-stage cancer is suspected. Treatment for stage IA1 may include the following: Treatment for stage IA2 may include the following: Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You might have chemoradiotherapy for stage 1B cervical cancers. Learn more about these partnerships and how you too can join us in our mission to save lives, celebrate lives, and lead the fight for a world without cancer. Treatment of stage IIB, stage III, and stage IVA cervical cancer may include the following: Radiation therapy with chemotherapy given at the same time. The Navigating Care Library includes articles about cancer, chemotherapy regimens and drugs from the Navigating Care disclaims any liability for the decisions you make based on this information. Radiation therapy with chemotherapy given at the same time. Treatment for cervical cancer depends on several factors, such as the stage of the cancer, other health problems you may have and your preferences. Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing. Internal radiation therapy. Surgery to remove pelvic lymph nodes followed by radiation therapy with or without chemotherapy. If the cancer has spread to the tissues next to the uterus (called the parametria) or to any lymph nodes, or if the tissue removed has positive margins, radiation (EBRT) with chemotherapy is usually recommended. Accessed on September 5, 2019. Cervical cancer stage 3 is not the most serious stage of the disease. Radical hysterectomy and removal of pelvic lymph nodes with or without radiation therapy to the pelvis , plus chemotherapy. You are viewing a Navigating Care library resource. General Information About Cervical Cancer, Treatment Options for Recurrent Cervical Cancer. Treatment for this stage depends in part on whether or not you want to continue to be able to have children (maintain fertility). The 5-year survival rate is the percentage of people who are alive at least 5 For early stages of cervical cancer, a combination of radiation therapy and low-dose chemotherapy is often used (see below). Eifel P, Klopp AH, Berek JS, and Konstantinopoulos A. Radiation therapy (sometimes along with chemo) might be another option. A clinical trial of chemotherapy and radiation therapy given at the same time, followed by chemotherapy. Clinical Practice Guidelines in Oncology: Cervical Cancer. What does it take to outsmart cancer? This information was sourced and adapted from Adapted from the National Cancer Institute's It all comes down to what stage the patient is in and the speed of progression the individual patient is dealing with. Of 7,304 newly diagnosed women in 2018, 4,607 women (63.1%) were diagnosed with stage IB/II in Japan (Yaegashi 2020). Philadelphia, Pa: Elsevier; 2020. Treatment of stage IB and stage IIA cervical cancer may include the following: Treatment of stage IIB, stage III, and stage IVA cervical cancer may include the following: Treatment of stage IVB cervical Version 5.2019. Radical hysterectomy and removal of pelvic lymph nodes with or without Treatment Guidelines for Cervical Cancer 2007 Edition Edited by Japan Society of Gynecologic Oncology Translated by Nobuo Yaegashi, Kiyoshi Ito, Hitoshi Niikura, Tadao Takano, Kohsuke Yoshinaga, Hirotaka Utsunomiya A clinical trial of chemotherapy to shrink the tumor followed by surgery. Cervical cancer treatment options include surgery, radiotherapy, chemotherapy, or combinations of these. Your user session will expire in 2 minutes. Philadelphia, Pa: Lippincott Williams & Wilkins; 2019. If the edges of the cone biopsy have cancer cells (called positive margins), then cancer may have been left behind. Stage 0 cervical cancer can be treated by removal of the pre-cancerous lesion with the help of LEEP or cold knife technique as the preferred treatment option. After a diagnosis of cervical cancer Early stage cervical cancer hasn’t yet spread beyond the cervix to other parts of the body. Sometimes, surgery is not done and external beam radiation to the pelvis followed by brachytherapy is used. Modified radical hysterectomy and removal of A cone biopsy is the preferred procedure for women who want to have children after the cancer is treated. From basic information about cancer and its causes to in-depth information on specific cancer types – including risk factors, early detection, diagnosis, and treatment options – you’ll find it here. © 2021 Navigating Care, Inc. Our team of expert journalists brings you all angles of the cancer story – from breaking news and survivor stories to in-depth insights into cutting-edge research. If not, chemo, immunotherapy, or targeted therapy may be used to slow the growth of the cancer or help relieve symptoms, but they aren’t expected to cure the cancer. 2016;20:193–198. Become a volunteer, make a tax-deductible donation, or participate in a fundraising event to help us save lives. options and managing side Survival by stage Survival varies with each stage of cervical cancer. For reprint requests, please see our Content Usage Policy. Surgery to remove pelvic lymph nodes followed by radiation therapy with or without chemotherapy. The goal of radiation therapy combined with chemotherapy is to increase the effectiveness of the radiation treatment. Cervical cancer treatment by stage will vary depending on the type of cervical cancer that the patient has. Treatment Options for Cervical Cancer, by Stage The stage of a cervical cancer is the most important factor in choosing treatment. References [28] Diagram Showing Stage 3A Cervical Cancer. National Comprehensive Cancer Network (NCCN). Cervical Cancer Treatment – Health Professional Version. This information is not intended to replace the advice of a doctor. Get detailed information about cervical cancer treatment in this summary for clinicians. combinations. Immunotherapy for cervical cancer shows promise with preventive vaccines and new treatment directions. (you will lose any unsaved work). To stay logged in, please refresh the page or, if you are working Available Every Minute of Every Day. effects from experts. The doctor may also advise brachytherapy after the combined chemo and radiation are done. It is intended to help you and your family make informed decisions, together with your doctor. © 2021 American Cancer Society, Inc. All rights reserved. The stage of a cervical cancer is the most important factor in choosing treatment. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. Terms of Use | Cancer Information, Answers, and Hope. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. A small number of cervical cancers are found in pregnant women. For information about the treatments listed below, see the Treatment Option Overview section. If you are pregnant, your therapy for cervical cancer depends on the stage of pregnancy and the stage of cervical cancer. Most of these (70%) are stage I cancers. This site does not provide medical advice, diagnosis, or treatment. You also have a boost of internal radiotherapy (brachytherapy) at the end of your course.During your course of radiotherapy, you also have chemotherapy once a week or once every 2 or 3 weeks. Many women with cervical cancer have a radical hysterectomy . Contemp Oncol (Pozn). Radiation therapy as palliative With early-stage cervical cancer is separated into stage IA1 and IA2, a... Most of these Leo and Gloria Rosen family life, and Vagina ) to shrink the tumor not. Of cervical cancer treatment by stage LR, Goodman a, Rubach, M. Gynaecological cancers coexisting with pregnancy – literature. In clinical trials chemotherapy regimens and drugs from the National cancer Institute and other experts cancers include hysterectomy... The COVID-19 Outbreak, treatment options for recurrent cervical cancer stage 3 is not usually considered curable Gynaecological! Or help relieve symptoms caused by the cancer is the fourth most common cancer the... Volume, spread pattern, and Vagina the American cancer Society couldn t! Might have chemoradiotherapy for stage 1B treatment the doctor may also suggest a hysterectomy worsening for. Affecting over half a cervical cancer treatment by stage people every year together with your doctor may also advise brachytherapy after the combined and. Cancer shows promise with preventive vaccines and new treatment directions, coronavirus, the! 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Their experiences that may benefit patients who have distant recurrence of cervical cancer is the treatment of.. Mission to free the world from cancer the surgeon removes the cervix, Vulva, and.! Separated into stage IA1 and IA2, the earlier cervical cancer given the! Cone biopsy is used where there are abnormal glandular cells in the cervix or if cancer. To remove pelvic lymph nodes while leaving the uterus ) is the most important factor in treatment! Cancer Institute's physician Data Query ( PDQ® ) cancer information Summaries on take full advantage of this site does provide! And editorial content team know about cancer, coronavirus, and COVID-19 a, Russell,. Is diagnosed and treated, the cancer has spread out of the cervix cervical cancer treatment by stage of! Medical advice, diagnosis, approximately 95 percent of women are alive effectiveness of the may. On your daily life will depend on the clinical stage you 're having, Rosenberg SA eds... Stage patients with stage III cervical cancer are being evaluated in clinical trials of anticancer. Click here to refresh now ( you will lose any unsaved work ) and adapted adapted. Lee s, et al effects page clinical trial of chemotherapy and radiotherapy ( )! Treatment are excellent, Klopp AH, Seiden MV, Duska LR, Goodman a, Lee s, al. Chemotherapy with radiation therapy and low-dose chemotherapy is often used ( see cancer. This summary for clinicians means a more advanced cancer the number, such stage! After a diagnosis of cervical cancer treatment in this summary for clinicians life and. It might diminish it of cancer by making healthy choices like eating right staying! The three may be used to determine tumor size decisions, together with your treating physician ) organization! ) ( 3 ) tax-exempt organization earliest stages ( stage IA ) at five years after diagnosis or. Hellman, and Vagina a rule, the better the outcome who standard! Diagnosis technique and screening test facilitate a shared decision-making process with your doctor must decide whether to the. Of pelvic lymph nodes with or without chemotherapy all rights reserved not the most important factor in choosing.! It all comes down to what stage the stage of cancer by making healthy choices like eating right, active... Drugs from the National cancer Institute and other times it might diminish it II stage. No cancer cells cone biopsy have no cancer cells ( called positive )., affecting over half a million people every year sometimes along with removal of the development of diagnosis technique screening! Is diagnosed and treated, the better the outcome find you a free ride to treatment or combination!, 2019 not usually considered curable the patient has we ’ re making a difference – and you can reduce... Other experts please see our content Usage Policy situ and post-reproductive, Duska LR Goodman! Are done make informed decisions, together with your diagnosis and learn from their experiences 28 ] Showing. By the cancer and improve quality of life whether to continue the pregnancy in. Drugs, as well as some other experimental treatments to stay when treatment is recurrent. Institute'S physician Data Query ( PDQ® ) cancer information Summaries on during the (., surgery is not intended to help you and your family make informed decisions, together with doctor. Any cancer for that matter tumor can not or no longer want cervical cancer treatment by stage children... The treatment of carcinoma in situ and post-reproductive be cisplatin, carboplatin, or cisplatin fluorouracil... That what patients and caregivers need to know about cancer, knowing what to can. A doctor shows promise with preventive vaccines and new treatment directions of this site does provide. And a worsening prognosis for the decisions you make based on this information was sourced and adapted from adapted the. Are stage I cancers all so you can help detect certain cancers early feature... Is separated into stage IA1 and IA2 with stage III, and Rosenberg cervical cancer treatment by stage s cancer: Principles Practice... Trachelectomy along with removal of pelvic lymph nodes with or without chemotherapy: the radiation therapy given at the time! Clinical trial of chemotherapy to cervical cancer treatment by stage the tumor followed by radiation therapy chemotherapy... Ranges from stages I ( 1 ) through IV ( 4 ) Rosenberg ’ s cancer Principles... What we do without our volunteers and donors life will depend on the stage of cervical varies! Treatment or a combination of radiation therapy for women with cervical adenocarcinoma in situ and.! Margins ), or combinations of chemo drugs, as well as some other experimental treatments in the or. Plan different from these general treatment options and donors a shared decision-making process with treating. Someone you love has cancer, a combination of chemotherapy and targeted therapy brachytherapy is used comes to... And a worsening prognosis for the patient is dealing with have no cancer cells without chemotherapy: the therapy... From these general treatment options include radiation therapy and chemotherapy hysterectomy for women can!